Usually end-to-end encryption is required by government agencies or small group of “secure” speakers to protect mobile phone calls against wiretapping.
Protection is extremely strong: voice is encrypted on caller mobile phone and decrypted on called mobile phones, without any chance for intermediate devices (PBXs, routers, switches, firewalls) to be able to eavesdrop on the call.
This model is the same as PGP on email: only sender and receiver can encrypt/decrypt the content of their communication. No-one else, not even the owner of server can wiretap their communications.
This is the strongest model from the security point of view, called end-to-end encryption, that we enforce using the ZRTP protocol. It is the only model we provide in the SaaS mode and it does not provide integration with fixed lines.